She stressed the need to improve the tools and assessments readily available, stating that the approaches used for non-AD patients are not applicable for everyone.Ĭlick here for more coverage of SLEEP 2022. Benca, professor and chair, Psychiatry & Human Behavior, Wake Forest School of Medicine, sat down with NeurologyLive ® to discuss her presentation, including some of the complexities in conducting clinical trials that focus on sleep disorders in patients with AD. Some clinicians have turned to antipsychotic drugs, but these are considered with extreme caution, as studies have shown that these drugs are associated with increased risk of stroke and death in older adults with dementia.Īt the 2022 SLEEP Annual Meeting, June 4-8, in Charlotte, North Carolina, Ruth Benca, MD, PhD, presented on the impact and management of sleep problems in patients with AD and their caregivers. In some cases, nondrug approaches fail to work, or the sleep changes are accompanied by disruptive nighttime behaviors. This includes maintaining regular times for meals, encouraging regular daily exercise avoiding alcohol, caffeine, and nicotine and discouragement of watching television during periods of wakefulness, among others. Typically, nondrug treatment strategies for sleep changes are the first route taken by clinicians. The relationship between sleep issues and other symptoms of AD may be reciprocal as well, with sleep loss worsening other symptoms such as delusions, restlessness, and wandering. Sleep diaries can be a simple and cost-effective means of assessing sleep. People with AD experience sleep disturbances, including shorter or more fragmented sleep, changes to the biological clock and sleep cycle, and certain sleep disorders. An ever-growing volume of peer-reviewed publications speaks to the recent and. In addition to the numerous cognitive deficits patients with Alzheimer disease (AD) face, issues with sleep are also quite common, which can be disruptive to both the affected patient and their caregivers. There have been very few drugs that have been tested in patients with AD, and not a lot of that have been tested in older adults." We need good longitudinal studies of treatments for these patients. Methods and Results: Sleep diaries from the original. These nights were chosen to capture sleep at approximately 1 and 2 weeks of abstinence, 17 and to have an accommodation or re-accommodation night (Nights 3 and 10) for each subsequent data night (Nights 4 and 11). Study Objectives: To present an expert consensus, standardized, patient-informed sleep diary. "Having good clinical guidelines of how to assess and treat sleep problems in these patients, at the very least, are going to improve their quality of life and the quality of life of their caregivers. PSG sleep recordings were performed on Study Nights 3, 4, 10, and 11.
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